Statins urged for heart disease
Published: Wednesday, November 20, 2013 at 2:23 p.m.
Last Modified: Wednesday, November 20, 2013 at 2:23 p.m.
For decades, if you asked your doctor what your odds were of suffering a heart attack, the answer would turn on a number: your cholesterol level.
Now the nation's first new heart disease prevention guidelines in a decade take a very different approach, focusing more broadly on risk and moving away from specific targets for cholesterol.
The guidance offers doctors a new formula for estimating risk that includes age, gender, race and factors such as whether someone smokes.
And for the first time, the guidelines take aim at preventing strokes, not just heart attacks. Partly because of that, they set a lower threshold for using medicines to reduce risk. They recommend using statin drugs such as Lipitor and Zocor, and identify four groups of people they help the most.
The end result: Twice as many Americans — one-third of all adults — would be told to consider taking statins, which lower cholesterol but also reduce heart risks in other ways.
"The emphasis is to try to treat more appropriately," said Dr. Neil Stone, the Northwestern University doctor who headed the cholesterol guideline panel. "We're going to give statins to those who are the most likely to benefit."
Doctors say the new approach will limit how many people are put on statins simply because of a cholesterol number. Yet, under the new advice, one-third of U.S. adults — 44 percent of men and 22 percent of women — would meet the threshold to consider taking a statin. Under current guidelines, statins are recommended for about 15 percent of adults.
Heart disease is the leading cause of death worldwide. High cholesterol leads to hardened arteries that can cause a heart attack or stroke. Most cholesterol is made by the liver, so diet changes have a limited effect on it.
Current guidelines say total cholesterol should be under 200, and LDL, or "bad cholesterol," under 100. Other drugs such as niacin and fibrates are sometimes added to statins to try to reach those goals, but studies show they don't always lower the chances of heart problems.
"Chasing numbers can lead us to using drugs that haven't been proven to help patients. You can make someone's lab test look better without making them better," said Yale University cardiologist Dr. Harlan Krumholz, who has long urged the broader risk approach the new guidelines take.
They say statins do the most good for:
* People who already have heart disease.
* Those with LDL of 190 or higher, usually because of genetic risk.
* People ages 40 to 75 with Type 2 diabetes.
* People ages 40 to 75 who have an estimated 10-year risk of heart disease of 7.5 percent or higher, based on the new formula. (This means that for every 100 people with a similar risk profile, seven or eight would have a heart attack or stroke within 10 years.)
Despite a small increased risk of muscle problems and accelerating diabetes in patients already at risk for it, statins are "remarkably safe drugs" whose benefits outweigh their risks, said Dr. Donald Lloyd-Jones, preventive-medicine chief at Northwestern.
The patents on Lipitor, Zocor and other statins have expired, and they are widely available in generic versions for as little as a dime a day. One that is still under patent protection is AstraZeneca's Crestor, which had sales of $8.3 billion in 2012.
Aspirin — widely used to lower the risk of strokes and heart attacks — is not addressed in the guidelines. And many drugs other than statins are still recommended for certain people, such as those with high triglycerides.
Patients should not stop taking any heart drug without first checking with their doctor.